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DISHEVELLED PROTEINS
Descriptors Found:
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DeCS
Descriptor
English
:
Dishevelled Proteins
Descriptor
Spanish
:
Proteínas Dishevelled
Descriptor
Portuguese
:
Proteínas Desgrenhadas
Synonyms
English
:
Dishevelled Protein
Dishevelled-1 Protein
Dishevelled-2 Protein
Dishevelled-3 Protein
Dishevelled 1 Protein
Dishevelled 2 Protein
Dishevelled 3 Protein
Tree Number:
D12.644.360.024.288
D12.776.157.057.025
D12.776.476.024.376
Definition
English
:
A
family
of
proteins
that are key components of the
WNT SIGNALING PATHWAY
, where they function downstream of
FRIZZLED RECEPTORS
. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the
CELL MEMBRANE
.
Dishevelled proteins
have important functions in
CELL DIFFERENTIATION
and establishing
CELL POLARITY.
History Note
English
:
2017 (1994)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56535
Unique Identifier:
D000072261
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS